Deutsch Intern
    FP7 Project 202222 - Predict IV

    Publications

    Peer-reviewed publications supported by PredictIV

    No Author Year Title Journal URL DOI
    1 Tuschl G, Hrach J, Walter Y, Hewitt PG and Mueller SO 2009 Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug-drug interaction studies Chem Biol Interact, 181(1):124-37 Link 10.1016/j.cbi.2009.05.015
    2 Antherieu S, Chesne C, Li R, Camus S, Lahoz A, Picazo L, Turpeinen M, Tolonen A, Uusitalo J, Guguen-Guillouzo C and Guillouzo A 2010 Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells Drug Metab Dispos, 38(3):516-25 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20019244 10.1124/dmd.109.030197
    3 Bielow C, Ruzek S, Huber CG and Reinert K 2010 Optimal decharging and clustering of charge ladders generated in ESI-MS J Proteome Res, 9(5):2688-95 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20201597 10.1021/pr100177k
    4 Bois FY, Jamei M and Clewell HJ 2010 PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals Toxicology, 278(3):256-67 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20600548 10.1016/j.tox.2010.06.007
    5 Guguen-Guillouzo C, Corlu A and Guillouzo A 2010 Stem cell-derived hepatocytes and their use in toxicology Toxicology, 270(1):3-9 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19815049 10.1016/j.tox.2009.09.019
    6 Guguen-Guillouzo C and Guillouzo A 2010 General Review on In Vitro Hepatocyte Models and Their Applications Methods in Mol Biol, 640(1-40 http://www.springerlink.com/content/n1q14q45l716n822/ - section=740471&page=1&locus=0 10.1007/978-1-60761-688-7_1
    7 Johnstone AF, Gross GW, Weiss DG, Schroeder OH, Gramowski A and Shafer TJ 2010 Microelectrode arrays: a physiologically based neurotoxicity testing platform for the 21st century Neurotoxicology, 31(4):331-50 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20399226 10.1016/j.neuro.2010.04.001
    8 Lauer B, Truisi GL and Hewitt PG 2010 Frühe Biomarker-basierte Risikobewertung der Leber- und Nierentoxizität Laborwelt, 3(10-12 http://www.laborwelt.de/service/suche.html?id=233&tx_lbwsearch_pi1%5Bq%5D=biomarker-basierte+Risikobewertung
    9 Lukas A and Mayer B 2010 Data annotation and relations modeling for integrated Omics in clinical research The IIOAB Journal, 1(2):15-23
    10 Antherieu S, Rogue A, Fromenty B, Guillouzo A and Robin MA 2011 Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells Hepatology, 53(6):1895-905 http://www.ncbi.nlm.nih.gov/pubmed/21391224 10.1002/hep.24290
    11 Bielow C, Aiche S, Andreotti S and Reinert K 2011 MSSimulator: Simulation of Mass Spectrometry Data J Proteome Res, 10(7):2922-2929 http://www.ncbi.nlm.nih.gov/pubmed/21526843 10.1021/pr200155f
    12 Bielow C, Gropl C, Kohlbacher O and Reinert K 2011 Bioinformatics for qualitative and quantitative proteomics Methods Mol Biol, 719:331-49 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21370091 10.1007/978-1-61779-027-0_15
    13 Wiesinger M, Haiduk M, Behr M, de Abreu Madeira HL, Glockler G, Perco P and Lukas A 2011 Data and knowledge management in cross-Omics research projects Methods Mol Biol, 719:97-111 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21370080 10.1007/978-1-61779-027-0_4
    14 Broeders JJ, Blaauboer BJ and Hermens JL 2011 Development of a negligible depletion-solid phase microextraction method to determine the free concentration of chlorpromazine in aqueous samples containing albumin Journal of chromatography. A, 1218(47):8529-35 http://www.ncbi.nlm.nih.gov/pubmed/21993514 10.1016/j.chroma.2011.09.064
    15 Cheng S and Bois FY 2011 A mechanistic modeling framework for predicting metabolic interactions in complex mixtures Environ Health Perspect, 119(12):1712-8 http://www.ncbi.nlm.nih.gov/pubmed/21835728 10.1289/ehp.1103510
    16 Limonciel A, Aschauer L, Wilmes A, Prajczer S, Leonard MO, Pfaller W and Jennings P 2011 Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes Toxicol In Vitro, 25(8):1855-1862 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21635945 10.1016/j.tiv.2011.05.018
    17 Novellino A, Scelfo B, Palosaari T, Price A, Sobanski T, Shafer TJ, Johnstone AF, Gross GW, Gramowski A, Schroeder O, Jugelt K, Chiappalone M, Benfenati F, Martinoia S, Tedesco MT, Defranchi E, D'Angelo P and Whelan M 2011 Development of micro-electrode array based tests for neurotoxicity: assessment of interlaboratory reproducibility with neuroactive chemicals Front Neuroeng, 4(4):1-14 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21562604 10.3389/fneng.2011.00004
    18 Schroeder K, Bremm KD, Alepee N, Bessems JG, Blaauboer B, Boehn SN, Burek C, Coecke S, Gombau L, Hewitt NJ, Heylings J, Huwyler J, Jaeger M, Jagelavicius M, Jarrett N, Ketelslegers H, Kocina I, Koester J, Kreysa J, Note R, Poth A, Radtke M, Rogiers V, Scheel J, Schulz T, Steinkellner H, Toeroek M, Whelan M, Winkler P and Diembeck W 2011 Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectors Toxicol In Vitro, 25(3):589-604 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21167275 10.1016/j.tiv.2010.12.005
    19 Wilmes A, Crean D, Aydin S, Pfaller W, Jennings P and Leonard MO 2011 Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity Toxicol In Vitro, 25(3):613-22 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21172416 10.1016/j.tiv.2010.12.009
    20 Bois F, Jamei M and Lyubimov AV 2012 Population-based pharmacokinetic modeling and simulation Encyclopedia of Drug Metabolism and Interactions http://onlinelibrary.wiley.com/doi/10.1002/9780470921920.edm135/abstract 10.1002/9780470921920.edm135
    21 Broeders J, Van Eijkeren JC, Blaauboer B and Hermens JL 2012 Transport of chlorpromazine in the Caco-2 cell permeability assay: a kinetic study Chem Res Toxicol, 25(7):1442-1451 http://www.ncbi.nlm.nih.gov/pubmed/22702643 10.1021/tx300221k
    22 Crean D, Felice L, Taylor CT, Rabb H, Jennings P and Leonard MO 2012 Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusion Mol Cell Biochem, 366(1-2):231-8 http://www.ncbi.nlm.nih.gov/pubmed/22460831 10.1007/s11010-012-1300-4
    23 Jennings P, Limonciel A, Felice L and Leonard MO 2012 An overview of transcriptional regulation in response to toxicological insult Arch Toxicol,  http://www.ncbi.nlm.nih.gov/pubmed/22926699 s00204-012-0919-y
    24 Junker J, Bielow C, Bertsch A, Sturm M, Reinert K and Kohlbacher O 2012 TOPPAS: A Graphical Workflow Editor for the Analysis of High-Throughput Proteomics Data Journal of proteome research, 11(7):3914-3920 http://www.ncbi.nlm.nih.gov/pubmed/22583024 10.1021/pr300187f
    25 Rogue A, Lambert C, Spire C, Claude N and Guillouzo A 2012 Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells Drug Metab Dispos, 40(1):151-8 http://www.ncbi.nlm.nih.gov/pubmed/21994436 10.1124/dmd.111.042028
    26 Sampath S, McLean LA, Buono C, Moulin P, Wolf A, Chibout SD, Pognan F, Busch S, Shangari N, Cruz E, Gurnani M, Patel P and Reising A 2012 The use of rat lens explant cultures to study the mechanism of drug-induced cataractogenesis Toxicol Sci, 126(1):128-39 http://www.ncbi.nlm.nih.gov/pubmed/22193206 10.1093/toxsci/kfr344
    27 Wiesinger M, Mayer B, Jennings P and Lukas A 2012 Comparative analysis of perturbed molecular pathways identified in in vitro and in vivo toxicology studies Toxicol In Vitro, 26(6):956-962 http://www.ncbi.nlm.nih.gov/pubmed/22515967 10.1016/j.tiv.2012.03.018
    28 Alice Limonciel, Anja Wilmes, Lydia Aschauer, Robert Radford, Katarzyna M. Bloch, Tara McMorrow, Walter Pfaller, Joost H. van Delft, Craig Slattery, Michael P. Ryan, Edward A. Lock, Paul Jennings 2012 Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells Archives of Toxicology, 86(11):1741-1751 link.springer.com/article/10.1007%2Fs00204-012-0897-0 10.1007/s00204-012-0897-0
    29 Homepage 2012 The impact of data transformations on concentration-response modeling Toxicology Letters 213(2):292+293 www.ncbi.nlm.nih.gov/pubmed/22828011 10.1016/j.toxlet.2012.07.012
    30 Anja Wilmes , Alice Limonciel, Lydia Aschauer, Konrad Moenks, Chris Bielow, Martin O. Leonard, Jeremy Hamon, Donatella Carpi, Silke Ruzek, Andreas Handler, Olga Schmal, Karin Herrgen, Patricia Bellwon, Christof Burek, Germaine L. Truisi, Philip Hewitt, Emma Di Consiglio, Emanuela Testai, Bas J. Blaauboer, Claude Guillou, Christian G. Huber, Arno Lukas, Walter Pfaller, Stefan O. Mueller, Frederic Y. Bois, Wolfgang Dekant, Paul Jennings 2013 Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress Journal of Proteomics, 79:180-194 www.sciencedirect.com/science/article/pii/S1874391912007774 10.1016/j.jprot.2012.11.022
    31 Sébastien Anthérieu, Pamela Bachour-El Azzi, Julie Dumont, Ziad Abdel-Razzak, Christiane Guguen-Guillouzo, Bernard Fromenty, Marie-Anne Robin and André Guillouzo 2013 Oxidative stress plays a major role in Chlorpromazine-induced cholestasis in human HepaRG cells Hepatology, 57(4):1518-1529 http://www.ncbi.nlm.nih.gov/pubmed/23175273 10.1002/hep.26160
    32 Lydia Aschauer, Leonhard N. Gruber, Walter Pfaller, Alice Limonciel, Toby J. Athersuch, Rachel Cavill, Abdulhameed Khan, Gerhard Gstraunthaler, Johannes Grillari, Regina Grillari, Philip Hewitt, Martin O. Leonard,gAnja Wilmes, Paul Jennings 2013 Delineation of the Key Aspects in the Regulation of Epithelial Monolayer Formation Mol Cell Biol, 33(13):2535-50 http://www.ncbi.nlm.nih.gov/pubmed/23608536 10.1128/MCB.01435-12
    33 Maria Renner, Marie-Gabrielle Zurich and Annette Kopp-Schneider 2013 Stochastic time-concentration activity models for cytotoxicity in 3D brain cell cultures Theoretical Biology and Medical Modelling, 10:1-19 http://www.ncbi.nlm.nih.gov/pubmed/23497233 10.1186/1742-4682-10-19
    34 Broeders, J.J., Blaauboer, B.J., Hermens, J.L. 2013 In vitro biokinetics of chlorpromazine and the influence of different dose metrics on effect concentrations for cytotoxicity in Balb/c 3T3, Caco-2 and HepaRG cell cultures Toxicology in Vitro, 27(3):1057-64 http://www.ncbi.nlm.nih.gov/pubmed/23376437 10.1016/j.tiv.2013.01.010
    35 Fabulas-da Costa A, Aijjou R, Hachani J, Landry C, Cecchelli R and Culot M 2013 In vitro blood-brain barrier model adapted to repeated-dose toxicological screening Toxicology in Vitro, 27(6):1944-53 http://www.ncbi.nlm.nih.gov/pubmed/23850739 10.1016/j.tiv.2013.06.026
    36 Parmentier C, Truisi GL, Moenks K, Stanzel S, Lukas A, Kopp-Schneider A, Alexandre E, Hewitt PG, Mueller SO and Richert L 2013 Transcriptomic Hepatotoxicity Signature of Chlorpromazine after Short- and Long-Term Exposure in Primary Human Sandwich Cultures Drug Metab Dispos, 41(10):1835-1842 http://www.ncbi.nlm.nih.gov/pubmed/23913027 10.1124/dmd.113.052415
    37 Bessems, JG, Loizou, G, Krishnan, K, Clewell, HJ, 3rd, Bernasconi, C, Bois, F, Coecke, S, Collnot, EM, Diembeck, W, Farcal, LR, Geraets, L, Gundert-Remy, U, Kramer, N, Kusters, G, Leite, SB, Pelkonen, OR, Schroder, K, Testai, E, Wilk-Zasadna, I, and Zaldivar-Comenges, JM 2013 PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: Recommendations from a joint EPAA - EURL ECVAM ADME workshop Reg Tox Pharm, epub http://www.ncbi.nlm.nih.gov/pubmed/24287156 10.1016/j.yrtph.2013.11.008
    38 Bois, F. 2013 Editorial: Computational pharmacokinetics at a crossroads In Silico Pharmacol, 1-5 http://www.in-silico-pharmacology.com/content/1/1/5 doi:10.1186/2193-9616-1-5
    39 Coecke, S., Pelkonen, O., Leite, S.B., Bernauer, U., Bessems, J.G., Bois, F.Y., Gundert-Remy, U., Loizou, G., Testai, E., Zaldivar 2013 Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches Toxicology in vitro, 27(5):1570-1577 http://www.ncbi.nlm.nih.gov/pubmed/22771339 10.1016/j.tiv.2012.06.012
    40 Crean, D., Felice, L., Pierre, P., Jennings, P., Leonard, M.O. 2013 Inhibition of protein translation as a mechanism of acidotic pH protection against ischaemic injury through inhibition of CREB mediated tRNA synthetase expression Experimental cell research, 319(20):3116-3127 http://www.ncbi.nlm.nih.gov/pubmed/23896026 10.1016/j.yexcr.2013.07.017
    41 Geenen, S., Yates, J.W., Kenna, J.G., Bois, F.Y., Wilson, I.D., Westerhoff, H.V 2013 Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats Integr Biol, 5(6):877-888 http://www.ncbi.nlm.nih.gov/pubmed/23632663 10.1039/c3ib20245c
    42 Borckholder, C., Heinzel, A., Kaniovskyi, Y., Benkner, S., Lukas, A., Mayer, B 2013 A Generic, Service-based Data Integration Framework Applied to Linking Drugs & Clinical Trials Procedia Computer Sci, 23:24-35 http://www.sciencedirect.com/science/article/pii/S187705091301140X 10.1016/j.procs.2013.10.005
    43 Ramirez, T., Daneshian, M., Kamp, H., Bois, F.Y., Clench, M.R., Coen, M., Donley, B., Fischer, S.M., Ekman, D.R., Fabian, E., Guillou, C., Heuer, J., Hogberg, H.T., Jungnickel, H., Keun, H.C., Krennrich, G., Krupp, E., Luch, A., Noor, F., Peter, E., Riefke, B., Seymour, M., Skinner, N., Smirnova, L., Verheij, E., Wagner, S., Hartung, T., van Ravenzwaay, B., Leist, M. 2013 Metabolomics in toxicology and preclinical research Altex, 30(2): 209-225 http://www.ncbi.nlm.nih.gov/pubmed/23665807
    44 Wilmes, A., Leonard, M.O., Jennings, P. 2013 Nrf2 inducibility of aldo-keto reductases Tox Lett, 221(1):39 http://www.ncbi.nlm.nih.gov/pubmed/23732362 10.1016/j.toxlet.2013.05.012
    45 Aschauer, L., Gruber, L. N., Pfaller, W., Limonciel, A., Athersuch, T. J., Cavill, R., Khan, A., Gstraunthaler, G., Grillari, J., Grillari, R., Hewitt, P., Leonard, M. O., Wilmes, A., Jennings, P. 2013 Delineation of the key aspects in the regulation of epithelial monolayer formation Mol Cell Biol, 33(13):2535-2550 http://www.ncbi.nlm.nih.gov/pubmed/23608536 10.1128/MCB.01435-12
    46 Wilmes, A., Aschauer, L., Limonciel, A., Pfaller, W., Jennings, P. 2014 Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel Tox Appl Pharm, 279(2):163-172 www.ncbi.nlm.nih.gov/pubmed/24907557 10.1016/j.taap.2014.05.013
    47 Sharanek, A., Azzi, P. B., Al-Attrache, H., Savary, C. C., Humbert, L., Rainteau, D., Guguen-Guillouzo, C., Guillouzo, A. 2014 Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells Tox Sci, 141(1):244-253 http://www.ncbi.nlm.nih.gov/pubmed/24973091 10.1093/toxsci/kfu122
    48 Hamon J., Jennings P., Bois F. 2014 Systems biology modeling of omics data: effect of cyclosporine a on the nrf2 pathway in human renal cells BMC Systems Biology, 8:76  http://www.ncbi.nlm.nih.gov/pubmed/24964791 10.1186/1752-0509-8-76
    49 Jiang X., Kopp-Schneider A. 2014 Summarizing EC50 estimates from multiple dose-response experiments: a comparison of a meta-analysis strategy to a mixed-effects model approach Biometrical Journal 56(3):493-512 www.ncbi.nlm.nih.gov/pubmed/24478144 10.1002/bimj.201300123
    50 Ranninger, C., Rurik, M., Limonciel, A., Ruzek, S., Reischl, R., Wilmes, A., Jennings, P., Hewitt, P., Dekant, W., Kohlbacher, O., Huber, C. G. 2015 Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline J Biol Chem, 290(31):19121-19132 www.ncbi.nlm.nih.gov/pubmed/26055719 10.1074/jbc.M115.644146
    51 Truisi, G. L., Consiglio, E. D., Parmentier, C., Savary, C. C., Pomponio, G., Bois, F., Lauer, B., Josse, R., Hewitt, P. G., Mueller, S. O., Richert, L., Guillouzo, A., Testai, E. 2015 Understanding the biokinetics of ibuprofen after single and repeated treatments in rat and human in vitro liver cell systems Tox Lett, 233(2):172-186 www.ncbi.nlm.nih.gov/pubmed/25578229 10.1016/j.toxlet.2015.01.006
    52 Pfaller, W., Prieto, P., Dekant, W., Jennings, P., Blaauboer, B. J. 2015 The Predict-IV project: Towards predictive toxicology using in vitro techniques Toxicology in vitro, 30(1A):1-3 http://www.ncbi.nlm.nih.gov/pubmed/26653009 10.1016/j.tiv.2015.10.006
    53 Mueller, S. O., Dekant, W., Jennings, P., Testai, E., Bois, F. 2015 Comprehensive summary--Predict-IV: A systems toxicology approach to improve pharmaceutical drug safety testing Toxicology in vitro, 30(1A):4-6 http://www.ncbi.nlm.nih.gov/pubmed/25450741 10.1016/j.tiv.2014.09.016
    54 Limonciel, A., Moenks, K., Stanzel, S., Truisi, G. L., Parmentier, C., Aschauer, L., Wilmes, A., Richert, L., Hewitt, P., Mueller, S. O., Lukas, A., Kopp-Schneider, A., Leonard, M. O., Jennings, P. 2015 Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing Toxicology in vitro, 30(1A):7-18 http://www.ncbi.nlm.nih.gov/pubmed/25596134 10.1016/j.tiv.2014.12.011
    55 Mueller, S. O., Guillouzo, A., Hewitt, P. G., Richert, L. 2015 Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project Toxicology in vitro, 30(1A):19-26 http://www.ncbi.nlm.nih.gov/pubmed/25952325 10.1016/j.tiv.2015.04.014
    56 Savary, C. C., Jiang, X., Aubry, M., Josse, R., Kopp-Schneider, A., Hewitt, P., Guillouzo, A. 2015 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period Toxicology in vitro, 30(1A):27-35 http://www.ncbi.nlm.nih.gov/pubmed/25572481 10.1016/j.tiv.2014.12.019
    57 Pomponio, G., Savary, C. C., Parmentier, C., Bois, F., Guillouzo, A., Romanelli, L., Richert, L., Di Consiglio, E., Testai, E. 2015 In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments Toxicology in vitro, 30(1A):36-51 http://www.ncbi.nlm.nih.gov/pubmed/25546373 10.1016/j.tiv.2014.12.012
    58 Broeders, J. J., Parmentier, C., Truisi, G. L., Josse, R., Alexandre, E., Savary, C. C., Hewitt, P. G., Mueller, S. O., Guillouzo, A., Richert, L., van Eijkeren, J. C., Hermens, J. L., Blaauboer, B. J. 2015 Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure Toxicology in vitro, 30(1A):52-61 http://www.ncbi.nlm.nih.gov/pubmed/25458484 10.1016/j.tiv.2014.08.012
    59 Bellwon, P., Truisi, G. L., Bois, F. Y., Wilmes, A., Schmidt, T., Savary, C. C., Parmentier, C., Hewitt, P. G., Schmal, O., Josse, R., Richert, L., Guillouzo, A., Mueller, S. O., Jennings, P., Testai, E., Dekant, W. 2015 Kinetics and dynamics of cyclosporine A in three hepatic cell culture systems Toxicology in vitro, 30(1A):62-78 http://www.ncbi.nlm.nih.gov/pubmed/26193170 10.1016/j.tiv.2015.07.016
    60 Germano, D., Uteng, M., Pognan, F., Chibout, S. D., Wolf, A. 2015 Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment Toxicology in vitro, 30(1A):79-94 http://www.ncbi.nlm.nih.gov/pubmed/24933330 10.1016/j.tiv.2014.05.009
    61 Aschauer, L., Carta, G., Vogelsang, N., Schlatter, E., Jennings, P. 2015 Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1 Toxicology in vitro, 30(1A):95-105 http://www.ncbi.nlm.nih.gov/pubmed/25500123 10.1016/j.tiv.2014.12.003
    62 Aschauer, L., Limonciel, A., Wilmes, A., Stanzel, S., Kopp-Schneider, A., Hewitt, P., Lukas, A., Leonard, M. O., Pfaller, W., Jennings, P. 2015 Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study Toxicology in vitro, 30(1A):106-116 http://www.ncbi.nlm.nih.gov/pubmed/25450743 10.1016/j.tiv.2014.10.005
    63 Wilmes, A., Bielow, C., Ranninger, C., Bellwon, P., Aschauer, L., Limonciel, A., Chassaigne, H., Kristl, T., Aiche, S., Huber, C. G., Guillou, C., Hewitt, P., Leonard, M. O., Dekant, W., Bois, F., Jennings, P. 2015 Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics Toxicology in vitro, 30(1A):117-127 10.1016/j.tiv.2014.10.006 10.1016/j.tiv.2014.10.006
    64 Crean, D., Bellwon, P., Aschauer, L., Limonciel, A., Moenks, K., Hewitt, P., Schmidt, T., Herrgen, K., Dekant, W., Lukas, A., Bois, F., Wilmes, A., Jennings, P., Leonard, M. O. 2015 Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing Toxicology in vitro, 30(1A):128-137 http://www.ncbi.nlm.nih.gov/pubmed/25536518 10.1016/j.tiv.2014.11.015
    65 Schultz, L., Zurich, M. G., Culot, M., da Costa, A., Landry, C., Bellwon, P., Kristl, T., Hormann, K., Ruzek, S., Aiche, S., Reinert, K., Bielow, C., Gosselet, F., Cecchelli, R., Huber, C. G., Schroeder, O. H., Gramowski-Voss, A., Weiss, D. G., Bal-Price, A. 2015 Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models Toxicology in vitro, 30(1A):138-165 http://www.ncbi.nlm.nih.gov/pubmed/26026931 10.1016/j.tiv.2015.05.016
    66 Bellwon, P., Culot, M., Wilmes, A., Schmidt, T., Zurich, M. G., Schultz, L., Schmal, O., Gramowski-Voss, A., Weiss, D. G., Jennings, P., Bal-Price, A., Testai, E., Dekant, W. 2015 Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood-brain barrier Toxicology in vitro, 30(1A):166-175 http://www.ncbi.nlm.nih.gov/pubmed/25683621 10.1016/j.tiv.2015.01.003
    67 Vichi, S., Sandstrom von Tobel, J., Gemma, S., Stanzel, S., Kopp-Schneider, A., Monnet-Tschudi, F., Testai, E., Zurich, M. G. 2015 Cell type-specific expression and localization of cytochrome P450 isoforms in tridimensional aggregating rat brain cell cultures Toxicology in vitro, 30(1A):176-184 http://www.ncbi.nlm.nih.gov/pubmed/25795400 10.1016/j.tiv.2015.03.005
    68 Broeders, J. J., Hermens, J. L., Blaauboer, B. J., Zurich, M. G. 2015 The in vitro biokinetics of chlorpromazine and diazepam in aggregating rat brain cell cultures after repeated exposure Toxicology in vitro, 30(1A):185-191 http://www.ncbi.nlm.nih.gov/pubmed/25193744 10.1016/j.tiv.2014.07.015
    69 Pomponio, G., Zurich, M. G., Schultz, L., Weiss, D. G., Romanelli, L., Gramowski-Voss, A., Di Consiglio, E., Testai, E. 2015 Amiodarone biokinetics, the formation of its major oxidative metabolite and neurotoxicity after acute and repeated exposure of brain cell cultures Toxicology in vitro, 30(1A):192-202 http://www.ncbi.nlm.nih.gov/pubmed/25659768 10.1016/j.tiv.2015.01.012
    70 Hamon, J., Renner, M., Jamei, M., Lukas, A., Kopp-Schneider, A., Bois, F. Y. 2015 Quantitative in vitro to in vivo extrapolation of tissues toxicity Toxicology in vitro, 30(1A):203-216 www.ncbi.nlm.nih.gov/pubmed/25678044 10.1016/j.tiv.2015.01.011
    71 Kramer, N. I., Di Consiglio, E., Blaauboer, B. J., Testai, E. 2015 Biokinetics in repeated-dosing in vitro drug toxicity studies Toxicology in vitro, 30(1A):217-224 www.ncbi.nlm.nih.gov/pubmed/26362508 10.1016/j.tiv.2015.09.005
    72 Jennings P, Crean D, Aschauer L, Limonciel A, Moenks K, Kern G, Hewitt P, Lhotta K, Lukas A, Wilmes A, Leonard MO. 2015 Interleukin-19 as a translational indicator of renal injury Arch Toxicol, 89(1):101-106 www.ncbi.nlm.nih.gov/pubmed/24714768 10.1007/s00204-014-1237-3
    73 Jiang X., Kopp-Schneider A. 2015 Statistical strategies for averaging EC50 from multiple dose-response experiments Archives of Toxicology 89(11):2119-2127 http://www.ncbi.nlm.nih.gov/pubmed/25294322 10.1007/s00204-014-1350-3
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