Participant 11: NUID UCD
National University of Ireland, University College Dublin, Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences
Participant leader: Dr. Martin O. Leonard PhD
Relevant experience and laboratory resources:
The Conway Institute is a new development within UCD Dublin, a purpose built, state of the art research facility first opened in 2003 and now houses up to 400 researchers across four main disciplines. It contains numerous core facilities ranging from Proteomic, Genomic and Microarray / qRT-PCR, flow cytometry and transgenic laboratories. Within the Conway Institute, there are multiple facilities to study the effects of oxygen tension on cellular phenotype, including 4 state of the art hypoxia chambers with adjustable oxygen tension and the ability to adapt to novel perfusion culture. We have also recently acquired 2 high resolution fluorescence live cell imaging systems (Zeiss) with hypoxia chamber adaptive perfusion systems. Together with a highly experienced support staff, this research facility has the capability to provide every resource necessary for successful completion of this proposal. There are currently four main groups including Dr. Leonards who are actively involved in hypoxic research comprising up to 20 individuals. The experience of such a core unit of researchers within the Institute is a vital and relevant resource.
Principal staff involved:
Dr. Martin Leonard has recently been appointed (Oct 2005) as a senior research scientist within the school of medicine and medical sciences, UCD Dublin. He has been working within the Conway Institute since 2003 and has up to 7 post-doctoral experience in the field of nephrology and specifically the effects of altered oxygen tension on signaling pathway activation and gene expression within the kidney in disease states. He has to date 14 publications in high impact peer reviewed journals ranging from J Exp Med, PNAS and J Biol Chem.
Role of the participant in the project and main tasks:
The participant is responsible for the establishment and integration of static and perfusion culture systems to altered oxygen tension as defined in WP2.2 and 2.4.