Participant 18: DKFZ
Deutsche Krebsforschungszentrum (German Cancer Research Centre), Department of Biostatistics, Heidelberg, Germany
Participant leader: Prof. Dr. Annette Kopp-Schneider
Relevant experience and laboratory resources:
The Deutsches Krebsforschungszentrum (German Cancer Research Center, DKFZ) enjoys a worldwide reputation for excellence in basic and translational cancer research center and is one of the leading centers in that area. Founded in 1964 as a foundation under public law, the DKFZ has nowadays a staff of 1700 (person years), with more than 820 scientists (person years) and approximately 880 employees (person years) providing administrative and technical support. In 2007, the total budget amounted to 130 million Euro funded by the Federal German Government and the State of Baden-Württemberg and third-party funding. The DKFZ is a member institution of the Helmholtz Association which is Germany’s largest research organisation. The goals of the DKFZ are to contribute towards a better understanding of fundamental processes in cancer and to develop innovative methods of cancer diagnostics and therapy. The research programme is concentrated on seven main research areas: signalling pathways, cell biology and cancer; structural functional genomics; cancer risk factors and prevention; tumour immunology; innovative diagnosis, prevention and therapy; infection and cancer and Translational Cancer Research. The DKFZ offers outstanding facilities in which to carry out innovative, multidisciplinary research including state-of-the art scientific equipment. In a Central Core Facility it provides the following services to the scientists: Genome and Proteome Analysis, Microscopy including ultrastructural analysis, Animal Facility and associated services and Computer services and documentation.
The tasks of the Department of Biostatistics are the research and the consulting for the application of biostatistical methods in cancer research. Aims include the optimal and efficient use and development of biostatistical procedures for the experimental and the clinical cancer research given the department's mission to contribute by its expertise to the understanding, the prevention and the treatment of cancer. The approach is strongly interdisciplinary, combining biostatistical consulting, cooperation in research projects in collaboration with experimental units, and methodological statistical research. The Biostatistics Unit has long-term experience in evaluating data from in vitro studies and bioassays. We have especially acquired expertise for the evaluation of data obtained from rodent liver. For five years we have focused on the statistical analysis of gene and protein expression data which were generated in a large national research network. Also, we have coordinated the data collection for and analyzed the data set obtained from a national inter-laboratory study. We have recently started statistical support for ReProTect, providing expertise in study design and performing statistical evaluation for various in vitro tests for reproductive toxicity.
Principal staff involved:
Annette Kopp-Schneider (F), biostatistician, coordinates a small team focusing on preclinical biostatistics, i.e. statistical methods for in vitro and experimental in vivo studies. Ongoing projects are funded by ‘Deutsche Forschungsgemeinschaft’, ‘Bundesministerium für Bildung und Forschung’ and ECVAM. She is the (co)author of more than 50 peer reviewed papers.
Role of the participant in the project and main tasks:
The participant will contribute in WP5, in particular by developing biodynamic models and in WP1.