FP7 Project 202222 - Predict IV


    Peer-reviewed publications supported by PredictIV

    1Tuschl G, Hrach J, Walter Y, Hewitt PG and Mueller SO2009Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug-drug interaction studiesChem Biol Interact, 181(1):124-37Link10.1016/j.cbi.2009.05.015
    2Antherieu S, Chesne C, Li R, Camus S, Lahoz A, Picazo L, Turpeinen M, Tolonen A, Uusitalo J, Guguen-Guillouzo C and Guillouzo A2010Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cellsDrug Metab Dispos, 38(3):516-25http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2001924410.1124/dmd.109.030197
    3Bielow C, Ruzek S, Huber CG and Reinert K2010Optimal decharging and clustering of charge ladders generated in ESI-MSJ Proteome Res, 9(5):2688-95http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2020159710.1021/pr100177k
    4Bois FY, Jamei M and Clewell HJ2010PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicalsToxicology, 278(3):256-67http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2060054810.1016/j.tox.2010.06.007
    5Guguen-Guillouzo C, Corlu A and Guillouzo A2010Stem cell-derived hepatocytes and their use in toxicologyToxicology, 270(1):3-9http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1981504910.1016/j.tox.2009.09.019
    6Guguen-Guillouzo C and Guillouzo A2010General Review on In Vitro Hepatocyte Models and Their ApplicationsMethods in Mol Biol, 640(1-40http://www.springerlink.com/content/n1q14q45l716n822/ - section=740471&page=1&locus=010.1007/978-1-60761-688-7_1
    7Johnstone AF, Gross GW, Weiss DG, Schroeder OH, Gramowski A and Shafer TJ2010Microelectrode arrays: a physiologically based neurotoxicity testing platform for the 21st centuryNeurotoxicology, 31(4):331-50http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2039922610.1016/j.neuro.2010.04.001
    8Lauer B, Truisi GL and Hewitt PG2010Frühe Biomarker-basierte Risikobewertung der Leber- und NierentoxizitätLaborwelt, 3(10-12http://www.laborwelt.de/service/suche.html?id=233&tx_lbwsearch_pi1%5Bq%5D=biomarker-basierte+Risikobewertung
    9Lukas A and Mayer B2010Data annotation and relations modeling for integrated Omics in clinical researchThe IIOAB Journal, 1(2):15-23
    10Antherieu S, Rogue A, Fromenty B, Guillouzo A and Robin MA2011Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cellsHepatology, 53(6):1895-905http://www.ncbi.nlm.nih.gov/pubmed/2139122410.1002/hep.24290
    11Bielow C, Aiche S, Andreotti S and Reinert K2011MSSimulator: Simulation of Mass Spectrometry DataJ Proteome Res, 10(7):2922-2929http://www.ncbi.nlm.nih.gov/pubmed/2152684310.1021/pr200155f
    12Bielow C, Gropl C, Kohlbacher O and Reinert K2011Bioinformatics for qualitative and quantitative proteomicsMethods Mol Biol, 719:331-49http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2137009110.1007/978-1-61779-027-0_15
    13Wiesinger M, Haiduk M, Behr M, de Abreu Madeira HL, Glockler G, Perco P and Lukas A2011Data and knowledge management in cross-Omics research projectsMethods Mol Biol, 719:97-111http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2137008010.1007/978-1-61779-027-0_4
    14Broeders JJ, Blaauboer BJ and Hermens JL2011Development of a negligible depletion-solid phase microextraction method to determine the free concentration of chlorpromazine in aqueous samples containing albuminJournal of chromatography. A, 1218(47):8529-35http://www.ncbi.nlm.nih.gov/pubmed/2199351410.1016/j.chroma.2011.09.064
    15Cheng S and Bois FY2011A mechanistic modeling framework for predicting metabolic interactions in complex mixturesEnviron Health Perspect, 119(12):1712-8http://www.ncbi.nlm.nih.gov/pubmed/2183572810.1289/ehp.1103510
    16Limonciel A, Aschauer L, Wilmes A, Prajczer S, Leonard MO, Pfaller W and Jennings P2011Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimesToxicol In Vitro, 25(8):1855-1862http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2163594510.1016/j.tiv.2011.05.018
    17Novellino A, Scelfo B, Palosaari T, Price A, Sobanski T, Shafer TJ, Johnstone AF, Gross GW, Gramowski A, Schroeder O, Jugelt K, Chiappalone M, Benfenati F, Martinoia S, Tedesco MT, Defranchi E, D'Angelo P and Whelan M2011Development of micro-electrode array based tests for neurotoxicity: assessment of interlaboratory reproducibility with neuroactive chemicalsFront Neuroeng, 4(4):1-14http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2156260410.3389/fneng.2011.00004
    18Schroeder K, Bremm KD, Alepee N, Bessems JG, Blaauboer B, Boehn SN, Burek C, Coecke S, Gombau L, Hewitt NJ, Heylings J, Huwyler J, Jaeger M, Jagelavicius M, Jarrett N, Ketelslegers H, Kocina I, Koester J, Kreysa J, Note R, Poth A, Radtke M, Rogiers V, Scheel J, Schulz T, Steinkellner H, Toeroek M, Whelan M, Winkler P and Diembeck W2011Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectorsToxicol In Vitro, 25(3):589-604http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2116727510.1016/j.tiv.2010.12.005
    19Wilmes A, Crean D, Aydin S, Pfaller W, Jennings P and Leonard MO2011Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicityToxicol In Vitro, 25(3):613-22http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2117241610.1016/j.tiv.2010.12.009
    20Bois F, Jamei M and Lyubimov AV2012Population-based pharmacokinetic modeling and simulationEncyclopedia of Drug Metabolism and Interactionshttp://onlinelibrary.wiley.com/doi/10.1002/9780470921920.edm135/abstract10.1002/9780470921920.edm135
    21Broeders J, Van Eijkeren JC, Blaauboer B and Hermens JL2012Transport of chlorpromazine in the Caco-2 cell permeability assay: a kinetic studyChem Res Toxicol, 25(7):1442-1451http://www.ncbi.nlm.nih.gov/pubmed/2270264310.1021/tx300221k
    22Crean D, Felice L, Taylor CT, Rabb H, Jennings P and Leonard MO2012Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusionMol Cell Biochem, 366(1-2):231-8http://www.ncbi.nlm.nih.gov/pubmed/2246083110.1007/s11010-012-1300-4
    23Jennings P, Limonciel A, Felice L and Leonard MO2012An overview of transcriptional regulation in response to toxicological insultArch Toxicol, http://www.ncbi.nlm.nih.gov/pubmed/22926699s00204-012-0919-y
    24Junker J, Bielow C, Bertsch A, Sturm M, Reinert K and Kohlbacher O2012TOPPAS: A Graphical Workflow Editor for the Analysis of High-Throughput Proteomics DataJournal of proteome research, 11(7):3914-3920http://www.ncbi.nlm.nih.gov/pubmed/2258302410.1021/pr300187f
    25Rogue A, Lambert C, Spire C, Claude N and Guillouzo A2012Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cellsDrug Metab Dispos, 40(1):151-8http://www.ncbi.nlm.nih.gov/pubmed/2199443610.1124/dmd.111.042028
    26Sampath S, McLean LA, Buono C, Moulin P, Wolf A, Chibout SD, Pognan F, Busch S, Shangari N, Cruz E, Gurnani M, Patel P and Reising A2012The use of rat lens explant cultures to study the mechanism of drug-induced cataractogenesisToxicol Sci, 126(1):128-39http://www.ncbi.nlm.nih.gov/pubmed/2219320610.1093/toxsci/kfr344
    27Wiesinger M, Mayer B, Jennings P and Lukas A2012Comparative analysis of perturbed molecular pathways identified in in vitro and in vivo toxicology studiesToxicol In Vitro, 26(6):956-962http://www.ncbi.nlm.nih.gov/pubmed/2251596710.1016/j.tiv.2012.03.018
    28Alice Limonciel, Anja Wilmes, Lydia Aschauer, Robert Radford, Katarzyna M. Bloch, Tara McMorrow, Walter Pfaller, Joost H. van Delft, Craig Slattery, Michael P. Ryan, Edward A. Lock, Paul Jennings2012Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cellsArchives of Toxicology, 86(11):1741-1751link.springer.com/article/10.1007%2Fs00204-012-0897-010.1007/s00204-012-0897-0
    29Homepage2012The impact of data transformations on concentration-response modelingToxicology Letters 213(2):292+293www.ncbi.nlm.nih.gov/pubmed/2282801110.1016/j.toxlet.2012.07.012
    30Anja Wilmes , Alice Limonciel, Lydia Aschauer, Konrad Moenks, Chris Bielow, Martin O. Leonard, Jeremy Hamon, Donatella Carpi, Silke Ruzek, Andreas Handler, Olga Schmal, Karin Herrgen, Patricia Bellwon, Christof Burek, Germaine L. Truisi, Philip Hewitt, Emma Di Consiglio, Emanuela Testai, Bas J. Blaauboer, Claude Guillou, Christian G. Huber, Arno Lukas, Walter Pfaller, Stefan O. Mueller, Frederic Y. Bois, Wolfgang Dekant, Paul Jennings2013Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stressJournal of Proteomics, 79:180-194www.sciencedirect.com/science/article/pii/S187439191200777410.1016/j.jprot.2012.11.022
    31Sébastien Anthérieu, Pamela Bachour-El Azzi, Julie Dumont, Ziad Abdel-Razzak, Christiane Guguen-Guillouzo, Bernard Fromenty, Marie-Anne Robin and André Guillouzo2013Oxidative stress plays a major role in Chlorpromazine-induced cholestasis in human HepaRG cellsHepatology, 57(4):1518-1529http://www.ncbi.nlm.nih.gov/pubmed/2317527310.1002/hep.26160
    32Lydia Aschauer, Leonhard N. Gruber, Walter Pfaller, Alice Limonciel, Toby J. Athersuch, Rachel Cavill, Abdulhameed Khan, Gerhard Gstraunthaler, Johannes Grillari, Regina Grillari, Philip Hewitt, Martin O. Leonard,gAnja Wilmes, Paul Jennings2013Delineation of the Key Aspects in the Regulation of Epithelial Monolayer FormationMol Cell Biol, 33(13):2535-50http://www.ncbi.nlm.nih.gov/pubmed/2360853610.1128/MCB.01435-12
    33Maria Renner, Marie-Gabrielle Zurich and Annette Kopp-Schneider2013Stochastic time-concentration activity models for cytotoxicity in 3D brain cell culturesTheoretical Biology and Medical Modelling, 10:1-19http://www.ncbi.nlm.nih.gov/pubmed/2349723310.1186/1742-4682-10-19
    34Broeders, J.J., Blaauboer, B.J., Hermens, J.L.2013In vitro biokinetics of chlorpromazine and the influence of different dose metrics on effect concentrations for cytotoxicity in Balb/c 3T3, Caco-2 and HepaRG cell culturesToxicology in Vitro, 27(3):1057-64http://www.ncbi.nlm.nih.gov/pubmed/2337643710.1016/j.tiv.2013.01.010
    35Fabulas-da Costa A, Aijjou R, Hachani J, Landry C, Cecchelli R and Culot M2013In vitro blood-brain barrier model adapted to repeated-dose toxicological screeningToxicology in Vitro, 27(6):1944-53http://www.ncbi.nlm.nih.gov/pubmed/2385073910.1016/j.tiv.2013.06.026
    36Parmentier C, Truisi GL, Moenks K, Stanzel S, Lukas A, Kopp-Schneider A, Alexandre E, Hewitt PG, Mueller SO and Richert L2013Transcriptomic Hepatotoxicity Signature of Chlorpromazine after Short- and Long-Term Exposure in Primary Human Sandwich CulturesDrug Metab Dispos, 41(10):1835-1842http://www.ncbi.nlm.nih.gov/pubmed/2391302710.1124/dmd.113.052415
    37Bessems, JG, Loizou, G, Krishnan, K, Clewell, HJ, 3rd, Bernasconi, C, Bois, F, Coecke, S, Collnot, EM, Diembeck, W, Farcal, LR, Geraets, L, Gundert-Remy, U, Kramer, N, Kusters, G, Leite, SB, Pelkonen, OR, Schroder, K, Testai, E, Wilk-Zasadna, I, and Zaldivar-Comenges, JM2013PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: Recommendations from a joint EPAA - EURL ECVAM ADME workshopReg Tox Pharm, epubhttp://www.ncbi.nlm.nih.gov/pubmed/2428715610.1016/j.yrtph.2013.11.008
    38Bois, F.2013Editorial: Computational pharmacokinetics at a crossroadsIn Silico Pharmacol, 1-5http://www.in-silico-pharmacology.com/content/1/1/5doi:10.1186/2193-9616-1-5
    39Coecke, S., Pelkonen, O., Leite, S.B., Bernauer, U., Bessems, J.G., Bois, F.Y., Gundert-Remy, U., Loizou, G., Testai, E., Zaldivar2013Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approachesToxicology in vitro, 27(5):1570-1577http://www.ncbi.nlm.nih.gov/pubmed/2277133910.1016/j.tiv.2012.06.012
    40Crean, D., Felice, L., Pierre, P., Jennings, P., Leonard, M.O.2013Inhibition of protein translation as a mechanism of acidotic pH protection against ischaemic injury through inhibition of CREB mediated tRNA synthetase expressionExperimental cell research, 319(20):3116-3127http://www.ncbi.nlm.nih.gov/pubmed/2389602610.1016/j.yexcr.2013.07.017
    41Geenen, S., Yates, J.W., Kenna, J.G., Bois, F.Y., Wilson, I.D., Westerhoff, H.V2013Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and ratsIntegr Biol, 5(6):877-888http://www.ncbi.nlm.nih.gov/pubmed/2363266310.1039/c3ib20245c
    42Borckholder, C., Heinzel, A., Kaniovskyi, Y., Benkner, S., Lukas, A., Mayer, B2013A Generic, Service-based Data Integration Framework Applied to Linking Drugs & Clinical TrialsProcedia Computer Sci, 23:24-35http://www.sciencedirect.com/science/article/pii/S187705091301140X10.1016/j.procs.2013.10.005
    43Ramirez, T., Daneshian, M., Kamp, H., Bois, F.Y., Clench, M.R., Coen, M., Donley, B., Fischer, S.M., Ekman, D.R., Fabian, E., Guillou, C., Heuer, J., Hogberg, H.T., Jungnickel, H., Keun, H.C., Krennrich, G., Krupp, E., Luch, A., Noor, F., Peter, E., Riefke, B., Seymour, M., Skinner, N., Smirnova, L., Verheij, E., Wagner, S., Hartung, T., van Ravenzwaay, B., Leist, M.2013Metabolomics in toxicology and preclinical researchAltex, 30(2): 209-225http://www.ncbi.nlm.nih.gov/pubmed/23665807
    44Wilmes, A., Leonard, M.O., Jennings, P.2013Nrf2 inducibility of aldo-keto reductasesTox Lett, 221(1):39http://www.ncbi.nlm.nih.gov/pubmed/2373236210.1016/j.toxlet.2013.05.012
    45Aschauer, L., Gruber, L. N., Pfaller, W., Limonciel, A., Athersuch, T. J., Cavill, R., Khan, A., Gstraunthaler, G., Grillari, J., Grillari, R., Hewitt, P., Leonard, M. O., Wilmes, A., Jennings, P.2013Delineation of the key aspects in the regulation of epithelial monolayer formationMol Cell Biol, 33(13):2535-2550http://www.ncbi.nlm.nih.gov/pubmed/2360853610.1128/MCB.01435-12
    46Wilmes, A., Aschauer, L., Limonciel, A., Pfaller, W., Jennings, P.2014Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channelTox Appl Pharm, 279(2):163-172www.ncbi.nlm.nih.gov/pubmed/2490755710.1016/j.taap.2014.05.013
    47Sharanek, A., Azzi, P. B., Al-Attrache, H., Savary, C. C., Humbert, L., Rainteau, D., Guguen-Guillouzo, C., Guillouzo, A.2014Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cellsTox Sci, 141(1):244-253http://www.ncbi.nlm.nih.gov/pubmed/2497309110.1093/toxsci/kfu122
    48Hamon J., Jennings P., Bois F.2014Systems biology modeling of omics data: effect of cyclosporine a on the nrf2 pathway in human renal cellsBMC Systems Biology, 8:76 http://www.ncbi.nlm.nih.gov/pubmed/2496479110.1186/1752-0509-8-76
    49Jiang X., Kopp-Schneider A.2014Summarizing EC50 estimates from multiple dose-response experiments: a comparison of a meta-analysis strategy to a mixed-effects model approachBiometrical Journal 56(3):493-512www.ncbi.nlm.nih.gov/pubmed/2447814410.1002/bimj.201300123
    50Ranninger, C., Rurik, M., Limonciel, A., Ruzek, S., Reischl, R., Wilmes, A., Jennings, P., Hewitt, P., Dekant, W., Kohlbacher, O., Huber, C. G.2015Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational PipelineJ Biol Chem, 290(31):19121-19132www.ncbi.nlm.nih.gov/pubmed/2605571910.1074/jbc.M115.644146
    51Truisi, G. L., Consiglio, E. D., Parmentier, C., Savary, C. C., Pomponio, G., Bois, F., Lauer, B., Josse, R., Hewitt, P. G., Mueller, S. O., Richert, L., Guillouzo, A., Testai, E.2015Understanding the biokinetics of ibuprofen after single and repeated treatments in rat and human in vitro liver cell systemsTox Lett, 233(2):172-186www.ncbi.nlm.nih.gov/pubmed/2557822910.1016/j.toxlet.2015.01.006
    52Pfaller, W., Prieto, P., Dekant, W., Jennings, P., Blaauboer, B. J.2015The Predict-IV project: Towards predictive toxicology using in vitro techniquesToxicology in vitro, 30(1A):1-3http://www.ncbi.nlm.nih.gov/pubmed/2665300910.1016/j.tiv.2015.10.006
    53Mueller, S. O., Dekant, W., Jennings, P., Testai, E., Bois, F.2015Comprehensive summary--Predict-IV: A systems toxicology approach to improve pharmaceutical drug safety testingToxicology in vitro, 30(1A):4-6http://www.ncbi.nlm.nih.gov/pubmed/2545074110.1016/j.tiv.2014.09.016
    54Limonciel, A., Moenks, K., Stanzel, S., Truisi, G. L., Parmentier, C., Aschauer, L., Wilmes, A., Richert, L., Hewitt, P., Mueller, S. O., Lukas, A., Kopp-Schneider, A., Leonard, M. O., Jennings, P.2015Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testingToxicology in vitro, 30(1A):7-18http://www.ncbi.nlm.nih.gov/pubmed/2559613410.1016/j.tiv.2014.12.011
    55Mueller, S. O., Guillouzo, A., Hewitt, P. G., Richert, L.2015Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV projectToxicology in vitro, 30(1A):19-26http://www.ncbi.nlm.nih.gov/pubmed/2595232510.1016/j.tiv.2015.04.014
    56Savary, C. C., Jiang, X., Aubry, M., Josse, R., Kopp-Schneider, A., Hewitt, P., Guillouzo, A.2015Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week periodToxicology in vitro, 30(1A):27-35http://www.ncbi.nlm.nih.gov/pubmed/2557248110.1016/j.tiv.2014.12.019
    57Pomponio, G., Savary, C. C., Parmentier, C., Bois, F., Guillouzo, A., Romanelli, L., Richert, L., Di Consiglio, E., Testai, E.2015In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatmentsToxicology in vitro, 30(1A):36-51http://www.ncbi.nlm.nih.gov/pubmed/2554637310.1016/j.tiv.2014.12.012
    58Broeders, J. J., Parmentier, C., Truisi, G. L., Josse, R., Alexandre, E., Savary, C. C., Hewitt, P. G., Mueller, S. O., Guillouzo, A., Richert, L., van Eijkeren, J. C., Hermens, J. L., Blaauboer, B. J.2015Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposureToxicology in vitro, 30(1A):52-61http://www.ncbi.nlm.nih.gov/pubmed/2545848410.1016/j.tiv.2014.08.012
    59Bellwon, P., Truisi, G. L., Bois, F. Y., Wilmes, A., Schmidt, T., Savary, C. C., Parmentier, C., Hewitt, P. G., Schmal, O., Josse, R., Richert, L., Guillouzo, A., Mueller, S. O., Jennings, P., Testai, E., Dekant, W.2015Kinetics and dynamics of cyclosporine A in three hepatic cell culture systemsToxicology in vitro, 30(1A):62-78http://www.ncbi.nlm.nih.gov/pubmed/2619317010.1016/j.tiv.2015.07.016
    60Germano, D., Uteng, M., Pognan, F., Chibout, S. D., Wolf, A.2015Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatmentToxicology in vitro, 30(1A):79-94http://www.ncbi.nlm.nih.gov/pubmed/2493333010.1016/j.tiv.2014.05.009
    61Aschauer, L., Carta, G., Vogelsang, N., Schlatter, E., Jennings, P.2015Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1Toxicology in vitro, 30(1A):95-105http://www.ncbi.nlm.nih.gov/pubmed/2550012310.1016/j.tiv.2014.12.003
    62Aschauer, L., Limonciel, A., Wilmes, A., Stanzel, S., Kopp-Schneider, A., Hewitt, P., Lukas, A., Leonard, M. O., Pfaller, W., Jennings, P.2015Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic studyToxicology in vitro, 30(1A):106-116http://www.ncbi.nlm.nih.gov/pubmed/2545074310.1016/j.tiv.2014.10.005
    63Wilmes, A., Bielow, C., Ranninger, C., Bellwon, P., Aschauer, L., Limonciel, A., Chassaigne, H., Kristl, T., Aiche, S., Huber, C. G., Guillou, C., Hewitt, P., Leonard, M. O., Dekant, W., Bois, F., Jennings, P.2015Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokineticsToxicology in vitro, 30(1A):117-12710.1016/j.tiv.2014.10.00610.1016/j.tiv.2014.10.006
    64Crean, D., Bellwon, P., Aschauer, L., Limonciel, A., Moenks, K., Hewitt, P., Schmidt, T., Herrgen, K., Dekant, W., Lukas, A., Bois, F., Wilmes, A., Jennings, P., Leonard, M. O.2015Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testingToxicology in vitro, 30(1A):128-137http://www.ncbi.nlm.nih.gov/pubmed/2553651810.1016/j.tiv.2014.11.015
    65Schultz, L., Zurich, M. G., Culot, M., da Costa, A., Landry, C., Bellwon, P., Kristl, T., Hormann, K., Ruzek, S., Aiche, S., Reinert, K., Bielow, C., Gosselet, F., Cecchelli, R., Huber, C. G., Schroeder, O. H., Gramowski-Voss, A., Weiss, D. G., Bal-Price, A.2015Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro modelsToxicology in vitro, 30(1A):138-165http://www.ncbi.nlm.nih.gov/pubmed/2602693110.1016/j.tiv.2015.05.016
    66Bellwon, P., Culot, M., Wilmes, A., Schmidt, T., Zurich, M. G., Schultz, L., Schmal, O., Gramowski-Voss, A., Weiss, D. G., Jennings, P., Bal-Price, A., Testai, E., Dekant, W.2015Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood-brain barrierToxicology in vitro, 30(1A):166-175http://www.ncbi.nlm.nih.gov/pubmed/2568362110.1016/j.tiv.2015.01.003
    67Vichi, S., Sandstrom von Tobel, J., Gemma, S., Stanzel, S., Kopp-Schneider, A., Monnet-Tschudi, F., Testai, E., Zurich, M. G.2015Cell type-specific expression and localization of cytochrome P450 isoforms in tridimensional aggregating rat brain cell culturesToxicology in vitro, 30(1A):176-184http://www.ncbi.nlm.nih.gov/pubmed/2579540010.1016/j.tiv.2015.03.005
    68Broeders, J. J., Hermens, J. L., Blaauboer, B. J., Zurich, M. G.2015The in vitro biokinetics of chlorpromazine and diazepam in aggregating rat brain cell cultures after repeated exposureToxicology in vitro, 30(1A):185-191http://www.ncbi.nlm.nih.gov/pubmed/2519374410.1016/j.tiv.2014.07.015
    69Pomponio, G., Zurich, M. G., Schultz, L., Weiss, D. G., Romanelli, L., Gramowski-Voss, A., Di Consiglio, E., Testai, E.2015Amiodarone biokinetics, the formation of its major oxidative metabolite and neurotoxicity after acute and repeated exposure of brain cell culturesToxicology in vitro, 30(1A):192-202http://www.ncbi.nlm.nih.gov/pubmed/2565976810.1016/j.tiv.2015.01.012
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