Workpackage

Title of workpackage

WP1

Compound selection and generation of in vivo and in vitro database

WP2.1

Long-term human models for hepatotoxicity

WP2.2

Human based cellular systems for nephrotoxicity testing

WP2.3

In vitro models for CNS toxicity testing

WP2.4

Long-term human models for non target organ specific toxicity

WP2.5

Bioactivation and co-culture models for toxicity testing

WP3

Non animal-based models for in vitro kinetics and human kinetic prediction

WP4.1

“omics” profiling methods

WP4.2

High-content image analysis of toxic effects and identification of toxicity pathways in human cell models

WP5

An integrated modeling approach for in vitro - in vivo extrapolations

WP6

Monitoring European efforts, building blocks, and industry input/needs

WP7

Management, training, dissemination and exploitation of results